Update (22/03/2018): BioArctic received approval to include patients from Norway in its Phase I/II study for SC0806, a biodegradable device that supports nerve regeneration in spinal cord injury.


22/02/2018

A new approach to treat complete spinal cord injury combining drugs with a biodegradable device is being tested in Sweden and soon also in Estonia.

BioArctic, a Swedish company, is currently in Phase I/II trials for a complete spinal cord injury treatment. The product, known as SC0806, uses a biodegradable medical device in tandem with a drug to support nerve regeneration across the injured area of the spinal cord.

BioArctic’s biodegradable medical device nurtures the growth of central nerves in transplanted grafts of peripheral nerves that protect the new growth from inflammation at the injury. To stimulate nerve regeneration further, the device releases FGF1, a growth factor involved in neural regeneration and healing, as it degrades.

The human body is not able to naturally regenerate tissue after spinal cord injuries because of an imbalance of chemical signals in the neuroregenerative process. If successful, BioArctic’s Phase I/II trial could prove to be an important step forward in harnessing the body’s regenerative potential to restore damaged tissue in the spinal cord.

Among treatments that are currently approved and administered by doctors, there is no regenerative therapy — which restores the body’s healthy tissue — for complete spinal cord injury that is clinically feasible. Current clinical practices focus on eliminating further damage to the spinal cord in patients with spinal cord injury. Regenerative therapeutic approaches in development include cell-based delivery, biomolecule delivery, and scaffold-based strategies.

Fibroblast growth factor 1 (FGF1)

Initially, the trial included patients at the Karolisnka University Hospital in Stockholm, Sweden. Now, the Estonian Health Board granted inclusion of Estonian patients in the trial. This step could drive the PhaseI/II trial forward by increasing and diversifying the patient sample population. In the future, BioArctic hopes to includes patients from Finland and Norway as well.

Spinal cord injury commonly arises from road traffic crashes, as well as work or sports related injuries. Spinal cord injury affects between 250,000 and 500,000 people worldwide each year, of which 40% have chronic cases. As a result, spinal cord injury poses a significant cost to healthcare systems.

Biodegradable tissue scaffold in combination with medicinal products may offer a promising means of treating cases that are not preventable. Among all of the therapies currently in development, BioArctic’s SC806 stands out because it targets patients with complete spinal cord injury, as opposed to patients with partial or acute injuries.


Images by molekuul_be, Alex Mit/Shutterstock

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  • John Harvey

    I sustained a partial SCI in my neck and then the the surgery left an infection which further damaged the SC from C-3 to C-7. I have 2 titanium scaffolds plus man-made discs to serve as replacements for the damaged collapsed discs. Thank God I can still wipe myself and type and walk (although without my walker I bounce off both walls as I walk down a corridor b/c my balance is shot. Etcetera, etc etc. I’ 65. The injury was from a fluke accident. Even though I was in tremendous shape from 30 yrs of strenuous back breaking work as a mason (brick & blocklayer) I am now, after 5 yrs, left w/ profound disabilities invluding balance, sensation, dexterity, chronic pain & atrophied muscles, esp my entire right side. If not for my own problems I sure wouldn’t have read this article. I salute the brilliant and persistent doctors & scientists and I hope they can fix me in a few yrs. PS> I did not sue anybody! b/c I know that none of the doctors did anything on purpose, even the first surgeon who infected me plus installed the synthetic discs w/ screws that were TOO LONG, entering the spinal canal. That was fixed by another surgeon who removed all the hardware from the first surgery and replaced the parts tnen installed another scaffold & man-made disc on a lower section between C-5 & C-7. I would further elaborate but my fingers are hitting the wrong keys and I have spent too much time trying to type this. Thanks to all for listening.

  • Carlos Angulo

    wish I can volunteer

  • Tigger

    I wonder if it will work for those with prior injuries, not just immediately after the injury. The article doesn’t state which it’s being used on in the trial.