Ablynx richly rewarded for MSD’s Nanobody Proof in Immuno-Oncology

Ablynx – the Belgian nanobody biotech (which uses monoclonal antibodies of Alpacas), has now achieved it’s first pre-clinical milestone in its immuno-oncology partnership with MSD (Merck & Co). Now Ablynx has achieved proof of concept for one of the 17 Nanobodies being studied. Ablynx has therefore received the first €3.5M in milestone payments from MSD for use of its Nanobody platform and running of trials to develop these tumor-targeting therapies.

Picture9Based in Ghent (Belgium), Ablynx partnered with Merck & Co. (MSD) for a €33M upfront deal made in February last year, with promise of further milestone-related payments to total €1.7Bn down the road. In return, MSD would license out Ablynx’s Camelidae (Alpaca) derived Nanobody platform and have trials run by Ablynx on several pre-selected candidates for research of potential immuno-oncology therapies.

The partnership seemed to thrive and offer great potential for MSD’s weakened pipeline, with MSD then going on to upgrade the partnership to a massive €5.7Bn in July. This extended the program to study a total of 17 Nanobody candidates, which have now been shown to function in targeting tumor-cells at multiple targets – i.e. they are ‘bi-specific’ and in some cases also ‘tri-specific’.

ADVERTISEMENT

The Ablynx Nanobody platform is derived from Camelidae (Alpaca) anti-bodies The Ablynx Nanobody platform is developed from Camelidae (Alpaca) anti-bodies (Source: Ablynx)

The Ablynx Nanobody platform is developed from Camelidae (Alpaca) anti-bodies which are smaller and multi-specific (Source: Ablynx)

Ablynx are famously well connected in the biotech industry, with many huge pharmas licensing out their Alpaca-nanobody tech. Partnerships include AbbVie (Immunology), Boehringer Ingelheim, Genzyme (Multiple Sclerosis/CNS), Novartis, Merck (in Neurology) and of course MSD (aka Merck & Co.).

Evidently Ablynx’s platform is still hugely desirable in the biotech industry, and will continue to be a real money-spinner if these MSD candidates stay on track for human trials.

Let's Continue The Conversation

Feel free to send us comments about this article to comments@labiotech.eu and/or comment on that article on social media.

We use cookies to give you the best experience and for advertising purposes. By accepting, you support our independent media and it's freely accessible content.